Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders
Identifieur interne : 000047 ( Main/Exploration ); précédent : 000046; suivant : 000048Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders
Auteurs : Susan R. Criswell [États-Unis] ; Joel S. Perlmutter [États-Unis] ; John L. Huang [États-Unis] ; Nima Golchin [États-Unis] ; Hubert P. Flores [États-Unis] ; Angela Hobson [États-Unis] ; Michael Aschner [États-Unis] ; Keith M. Erikson [États-Unis] ; Harvey Checkoway [États-Unis] ; Brad A. Racette [États-Unis]Source :
- Occupational and Environmental Medicine [ 1351-0711 ] ; 2012-06.
Abstract
Objectives Manganese exposure leads to diffuse cerebral metal deposition with the highest concentration in the globus pallidus associated with increased T1-weighted MRI signal. T1 signal intensity in extra-pallidal basal ganglia (caudate and putamen) has not been studied in occupationally exposed workers. Diffusion weighted imaging is a non-invasive measure of neuronal damage and may provide a quantification of neurotoxicity associated with welding and manganese exposure. This study investigated extra-pallidal T1 basal ganglia signal intensity as a marker of manganese exposure and basal ganglia diffusion weighted imaging abnormalities as a potential marker of neurotoxicity. Methods A 3T MR case:control imaging study was performed on 18 welders and 18 age- and gender-matched controls. Basal ganglia regions of interest were identified for each subject. T1-weighted intensity indices and apparent diffusion coefficients were generated for each region. Results All regional indices were higher in welders than controls (p≤0.05). Combined basal ganglia (ρ=0.610), caudate (ρ=0.645), anterior (ρ=0.595) and posterior putamen (ρ=0.511) indices were more correlated with exposure than pallidal (ρ=0.484) index. Welder apparent diffusion coefficient values were lower than controls for globus pallidus (p=0.03) and anterior putamen (p=0.004). Conclusions Welders demonstrated elevated T1 indices throughout the basal ganglia. Combined basal ganglia, caudate and putamen indices were more correlated with exposure than pallidal index suggesting more inclusive basal ganglia sampling results in better exposure markers. Elevated indices were associated with diffusion weighted abnormalities in the pallidum and anterior putamen suggesting neurotoxicity in these regions.
Url:
DOI: 10.1136/oemed-2011-100119
Affiliations:
- États-Unis
- Caroline du Nord, Missouri (État), Tennessee, Washington (État)
- Saint-Louis (Missouri)
- École de médecine (Université Washington de Saint-Louis)
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Flores</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Hobson, Angela" sort="Hobson, Angela" uniqKey="Hobson A" first="Angela" last="Hobson">Angela Hobson</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>American Parkinson Disease Association Advanced Center for Parkinson Research, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Aschner, Michael" sort="Aschner, Michael" uniqKey="Aschner M" first="Michael" last="Aschner">Michael Aschner</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Erikson, Keith M" sort="Erikson, Keith M" uniqKey="Erikson K" first="Keith M" last="Erikson">Keith M. Erikson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, University of North Carolina-Greensboro, Greensboro, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Checkoway, Harvey" sort="Checkoway, Harvey" uniqKey="Checkoway H" first="Harvey" last="Checkoway">Harvey Checkoway</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Racette, Brad A" sort="Racette, Brad A" uniqKey="Racette B" first="Brad A" last="Racette">Brad A. Racette</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>American Parkinson Disease Association Advanced Center for Parkinson Research, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Occupational and Environmental Medicine</title><title level="j" type="abbrev">Occup Environ Med</title><idno type="ISSN">1351-0711</idno><idno type="eISSN">1470-7926</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2012-06">2012-06</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="437">437</biblScope></imprint><idno type="ISSN">1351-0711</idno></series><idno type="istex">9E73C1CBFAC19305105A94BF2B5F7D538A426F73</idno><idno type="DOI">10.1136/oemed-2011-100119</idno><idno type="href">oemed-69-437.pdf</idno><idno type="ArticleID">oemed-2011-100119</idno><idno type="PMID">22447645</idno><idno type="local">oemed;69/6/437</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-0711</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objectives Manganese exposure leads to diffuse cerebral metal deposition with the highest concentration in the globus pallidus associated with increased T1-weighted MRI signal. T1 signal intensity in extra-pallidal basal ganglia (caudate and putamen) has not been studied in occupationally exposed workers. Diffusion weighted imaging is a non-invasive measure of neuronal damage and may provide a quantification of neurotoxicity associated with welding and manganese exposure. This study investigated extra-pallidal T1 basal ganglia signal intensity as a marker of manganese exposure and basal ganglia diffusion weighted imaging abnormalities as a potential marker of neurotoxicity. Methods A 3T MR case:control imaging study was performed on 18 welders and 18 age- and gender-matched controls. Basal ganglia regions of interest were identified for each subject. T1-weighted intensity indices and apparent diffusion coefficients were generated for each region. Results All regional indices were higher in welders than controls (p≤0.05). Combined basal ganglia (ρ=0.610), caudate (ρ=0.645), anterior (ρ=0.595) and posterior putamen (ρ=0.511) indices were more correlated with exposure than pallidal (ρ=0.484) index. Welder apparent diffusion coefficient values were lower than controls for globus pallidus (p=0.03) and anterior putamen (p=0.004). Conclusions Welders demonstrated elevated T1 indices throughout the basal ganglia. Combined basal ganglia, caudate and putamen indices were more correlated with exposure than pallidal index suggesting more inclusive basal ganglia sampling results in better exposure markers. Elevated indices were associated with diffusion weighted abnormalities in the pallidum and anterior putamen suggesting neurotoxicity in these regions.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Missouri (État)</li><li>Tennessee</li><li>Washington (État)</li></region><settlement><li>Saint-Louis (Missouri)</li></settlement><orgName><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Criswell, Susan R" sort="Criswell, Susan R" uniqKey="Criswell S" first="Susan R" last="Criswell">Susan R. Criswell</name></region><name sortKey="Aschner, Michael" sort="Aschner, Michael" uniqKey="Aschner M" first="Michael" last="Aschner">Michael Aschner</name><name sortKey="Checkoway, Harvey" sort="Checkoway, Harvey" uniqKey="Checkoway H" first="Harvey" last="Checkoway">Harvey Checkoway</name><name sortKey="Criswell, Susan R" sort="Criswell, Susan R" uniqKey="Criswell S" first="Susan R" last="Criswell">Susan R. Criswell</name><name sortKey="Criswell, Susan R" sort="Criswell, Susan R" uniqKey="Criswell S" first="Susan R" last="Criswell">Susan R. Criswell</name><name sortKey="Erikson, Keith M" sort="Erikson, Keith M" uniqKey="Erikson K" first="Keith M" last="Erikson">Keith M. Erikson</name><name sortKey="Flores, Hubert P" sort="Flores, Hubert P" uniqKey="Flores H" first="Hubert P" last="Flores">Hubert P. Flores</name><name sortKey="Golchin, Nima" sort="Golchin, Nima" uniqKey="Golchin N" first="Nima" last="Golchin">Nima Golchin</name><name sortKey="Hobson, Angela" sort="Hobson, Angela" uniqKey="Hobson A" first="Angela" last="Hobson">Angela Hobson</name><name sortKey="Hobson, Angela" sort="Hobson, Angela" uniqKey="Hobson A" first="Angela" last="Hobson">Angela Hobson</name><name sortKey="Huang, John L" sort="Huang, John L" uniqKey="Huang J" first="John L" last="Huang">John L. Huang</name><name sortKey="Huang, John L" sort="Huang, John L" uniqKey="Huang J" first="John L" last="Huang">John L. Huang</name><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name><name sortKey="Racette, Brad A" sort="Racette, Brad A" uniqKey="Racette B" first="Brad A" last="Racette">Brad A. Racette</name><name sortKey="Racette, Brad A" sort="Racette, Brad A" uniqKey="Racette B" first="Brad A" last="Racette">Brad A. Racette</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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